Dubois' Sea Snake Bite (2023)

Last updated June 25, 2019

Approved by: Krish Tangella MD, MBA, FCAP ; Krish Tangella MD, MBA, FCAP

Dubois' Sea Snake Bite (1)

The Dubois' sea snake (Aipysurus duboisii) may be described as a venomous coral reef snake belonging to the family Elapidae, which generally includes slender and swift moving snakes.

What are the other Names for this Condition? (Also known as/Synonyms)

  • Aipysurus Duboisii Snake Bite
  • Reef Shallows Sea Snake Bite

What is Dubois' Sea Snake Bite? (Definition/Background Information)

  • The Dubois' sea snake (Aipysurus duboisii) may be described as a venomous coral reef snake belonging to the family Elapidae, which generally includes slender and swift moving snakes. These snakes are mostly observed in the north Australian waters and around a few tropical islands in the southwestern Pacific Ocean
  • This snake is found among shallow coral reef waters and sandy bottoms and is considered a “truly aquatic” sea snake. Thus, Dubois’ sea snakes are completely adapted to marine life and habitat; they also have no terrestrial association and necessity to “visit land” for activities, such as nesting, laying eggs, or resting, like some other sea snakes do
  • An adult Dubois’ sea snake may range in size from 2 to 5 feet. The diet of these snakes include coral reef fish (parrotfish and surgeonfish), moray eels, bony fish, etc. and they mostly hunt during dusk
  • In general, the snake has a medium body with a small (slightly wide) head and slender neck. The body of the snake is of uniform size and of variable coloration; and, the tail is flattened (paddle-like) to help it swim
  • The Dubois’ sea snake may be in color shades that range from brown, beige, to purple; the sides and belly may be off white to dark brown. The dorsal surface is marked by dark blotches that drop to both sides in a “V” shaped pattern outlining the scales
  • Mostly, it is the fishing and coral reef diving communities in the endemic regions, which come into accidental contact with this sea creature. The Dubois’ sea snake is known to be slightly irritable and will attack if provoked
  • In some cases, sea snake bites may go unnoticed; the bites are also quite painless or produce minimal pain; the fangs of the snake are also very tiny (less than 2 mm). Nonetheless, the Dubois’ Sea Snake Bite can cause life-threatening to fatal envenomation (venom injection), without prompt and adequate treatment. It is important to note that there is contradicting literature on the venom toxicity; some reports indicate that the snake is highly venomous
  • The signs and symptoms of Dubois’ Sea Snake Bite may be apparent within a few hours following the bite. The snake venom is a potent neurotoxin, which can cause systemic symptoms such as severe fatigue, muscle weakness, respiratory failure, and total paralysis
  • Early administration of suitable antivenom (or antivenin) is the mainstay of treatment. Apart from this, symptomatic treatment is necessary, which may include pain medication, hydration, and respiratory support. The prognosis of Dubois’ Sea Snake Bite with immediate and effective therapy is usually good

Who gets Dubois' Sea Snake Bite? (Age and Sex Distribution)

  • Dubois’ Sea Snake Bite may occur to any individual exposed to the snake, usually near or around the coral reefs (when fishing or diving)
  • Individuals of any age and gender are prone to sea snake bites in the endemic zones
  • Thegeographical distribution of the Dubois’ sea snake include the following:
    • Northern and western parts of Australia bordering the states of Western Australia, Northern Territory, and Queensland
    • Island nations to the north of Australiaincluding New Guinea (part of Indonesia), Papua New Guinea, New Caledonia, Loyalty Islands, etc.
    • Great Barrier Reef off the east Australian coast

What are the Risk Factors for Dubois' Sea Snake Bite? (Predisposing Factors)

The risks forDubois’ Sea Snake Biteinclude the following factors:

  • Coral reef divers have the highest risk for being bitten by the Dubois’ sea snake, in the endemic areas
  • Living or residing in the coastal regions endemic to the snake
  • Fishermen and fisherwomen, while sorting fish, setting out fishing nets, pulling in the ‘catch’
  • Swimmers, surfers, and beachgoers
  • Marine life enthusiasts and scientific study groups, who explore the region
  • Wading in ocean waters without suitable protective clothing
  • Walking barefoot on the beach or in shallow sea waters
  • Keeping them as pets in aquariums (exotic collection)
  • Handling dead or live snakes; intentionally or accidentally picking up the snake

It is important to note that having a risk factor does not mean that one will get the condition. A risk factor increases one’s chances of getting a condition compared to an individual without the risk factors. Some risk factors are more important than others.

Also, not having a risk factor does not mean that an individual will not get the condition. It is always important to discuss the effect of risk factors with your healthcare provider.

What are the Causes of Dubois' Sea Snake Bite? (Etiology)

Dubois’ Sea Snake Bitecan take place when one comes into contact with the venomous sea snake, usually unintentionally or inadvertently.

  • Individuals, who come into contact with Dubois’ sea snake may be bitten under self defense when the snake is provoked, threatened, or handled; the snake is reportedly mildly aggressive and edgy
  • The snake venom contains strong neurotoxins (postsynaptic neurotoxins) that may cause paralysis and death. Even though envenomation is rare, the fast-acting venom can cause rapid muscle breakdown and neurological symptoms

According to scientific literature, sea snake venom is often many times more potent than land snake venom.

What are the Signs and Symptoms of Dubois' Sea Snake Bite?

The signs and symptoms of snake bites depend on the age (whether child or adult), body weight, and overall health status of the individual (whether having an underlying condition or illness). Also, the signs and symptoms vary according to the potency and amount of venom injected. However, in most cases, the venom of the Dubois’ sea snake is not known to severely affect humans.

The signs and symptoms of Dubois’ Sea Snake Bite can vary from one individual to another. Initial symptoms observed within a few hours after snake bite, may include:

  • Bite or fang marks on arm or leg; in some cases, the teeth may break-off and remain in the wound
  • There may be no pain to negligible pain and swelling at the bite site
  • Nausea, vomiting, and diarrhea
  • Sensation of thick tongue
  • Dryness of throat
  • Headaches
  • Feeling sweaty and/or thirsty
  • Anxiety, drowsiness, and confusion
  • Pain, fatigue, and weak muscles
  • Body aches and muscle aches; stiffness of the body and neck

Symptoms observed after several hours (4-8 hours or more) may include:

  • Abdominal pain
  • Poor reflexes
  • Locally enlarged lymph nodes
  • Drooling from the mouth; uncontrollable saliva flow from the mouth
  • Trismus or difficulty opening mouth (same as lockjaw)
  • Droopy eyelids and blurred vision
  • Breathing difficulties; labored breathing
  • Blabbering, speaking difficulties
  • Feeling faint or dizzy
  • Dark-colored urine
  • Blue-colored skin due to poisoning
  • Weakness and malaise
  • Unconsciousness

It has to be noted that in severe bites, the onset and development of symptoms may be rapid, within 1-2 hours. In such cases, the progress from early symptoms to paralysis, respiratory failure, and/or cardiac arrest may take place suddenly.

Systemicsigns and symptoms, in rare cases, may include:

  • Generalized muscle damage; progressive muscle weakness
  • Rhabdomyolysis: The skeletal muscle tissue may breakdown quickly
  • Paralysis of voluntary muscles; the affected individuals may be unable to stand, sit, or even raise their arms/legs or neck
  • Difficulty speaking and swallowing
  • Neurological symptoms including moderate to severe paralysis
  • Kidney injury causing acute kidney failure is reported
  • Multiple organs may be involved/affected


  • In some cases, the fang marks may not be pronounced or even visible. Sometimes, only small scratch marks or lacerations may be observed. Thus, any contact with a sea snake merits immediate medical attention
  • Severe anxiety may also result in some misleading symptoms of snakebites, such as sweating, fatigue, and shock, even when no bite has taken place (the individual may be imagining), or when it is a dry bite. Nevertheless, even in suspect cases, the presence of any such symptoms requires the attention of a qualified medical professional
  • Also, if the individual has been treated using alternative/native medicines, it may present additional confusing symptoms. Thus, it is important to always consult a qualified healthcare provider promptly

How is Dubois' Sea Snake Bite Diagnosed?

Dubois’ Sea Snake Bitemay be diagnosed using the following tests and exams:

  • Complete physical examination with comprehensive evaluation of medical history; a physical examination of the affected site by the physician may be normally sufficient to diagnose a snake bite
  • The individual may be asked to provide an account (history) of the events that occurred (what took place and how), if possible
  • Assessment of the signs and symptoms exhibited by the individual may be carefully observed
  • Blood tests that may include:
    • Complete blood count (CBC) with differential and platelet count
    • White blood cell count
    • Creatine kinase blood test
    • Lactate dehydrogenase (LDH) test
    • Serum electrolytes including blood urea nitrogen (BUN) and creatinine levels
    • Aspartate transaminase blood test
  • Urine test or urinalysis to test for free protein, myoglobin, and hemoglobin levels
  • Electrocardiogram or ECG, to check for arrhythmias (or irregular heartbeat) and hyperkalemia (increased blood potassium)
  • Kidney function test and liver function test, if necessary
  • Nerve conduction studies and neurological evaluation

Many clinical conditions may have similar signs and symptoms. Your healthcare provider may perform additional tests to rule out other clinical conditions to arrive at a definitive diagnosis.

What are the possible Complications of Dubois' Sea Snake Bite?

Rarely, the complications ofDubois’ Sea Snake Bitemay include:

  • Multiple bites, causing injection of a large quantity of venom
  • Breakdown ofmuscle tissue in the body or systemic myolysis
  • Tissue and muscle damage, which can result in superimposed infections
  • Flaccid paralysis that is severe; the onset of paralysis may occur within a few hours following the sea snake bite
  • Loss of respiratory function due to neurological symptoms, which can be fatal
  • Hyperkalemic cardiotoxicity due to muscle breakdown
  • Acute kidney failure
  • Cardiac failure
  • Coma

Presence of misleading symptoms due to fear and anxiety, which may be also aggravated by those around the individual, such as one’s family members, can sometimes result in inappropriate or over-treatment.

Antivenom reactions:

  • Some individuals may develop an allergic reaction, such as anaphylaxis, to the antivenom that may be serious. This may develop within 10 minutes or even after 6 hours, typically starting with itchiness over the scalp and other skin areas
  • Life-threatening anaphylactic reactions that require immediate medical treatment may include:
    • Low blood pressure or hypotension
    • Bronchospasm causing narrowing of the airways (bronchi) resulting in breathing difficulties
    • Angioedema: Swelling of skin tissue layers at various locations including the throat, causing speaking and breathing difficulties
  • Serum sickness may develop as a complication of antivenom therapy causing fever, nausea, itchy skin, muscle and joint pain, etc. It may develop after 4 days or even 2 weeks (average 7 days) following the administration of antivenom serum

How is Dubois' Sea Snake Bite Treated?

All sea snake bites should be considered as medical emergencies and evaluated by trained medical professionals, as soon as possible; the first 6-8 hours are particularly vital for preventing life-threatening symptoms. Failure to obtain early assessment and management from the highest level of care (available within the community) may potentially result in severe complications and death.

The following measures may be considered in the treatment ofDubois’ Sea Snake Bite, based on the medical evaluation of a trained healthcare professional. The snake bite can cause severe envenomation and hospitalization is generally necessary. In many cases, urgent first aid care and support, in the form of compression bandages, limb immobilization, and monitoring of vital signs is necessary and highly-recommended before the patient is hospitalized.

  • Administration of sea snake antivenom, to neutralize the venom through slow intravenous injection or infusion method
  • Address any signs or early allergic reaction: A close observation of the patient is necessary for a minimum of 60 minutes immediately following antivenom administration, to detect early allergic reactions, if any
  • Administration of intravenous fluids to keep the patient well-hydrated:
    • Good hydration is important, since potential myolysis (muscle breakdown) can cause severe failure of kidney function
    • Adequate hydration helps in decreasing the risk for kidney damage due to myolysis; hence, continuous measurement of urine output (day and night) is important
  • Periodic blood and urine tests are undertaken for 12-24 hours or more
  • Intubation and respiratory support is usually necessary
  • Tetanus vaccination is usually required, if it is not up to date
  • The patient is admitted and placed in an ICU setting and monitored for at least a day following the abatement of symptoms; the patient has to be rested and kept warm
  • Administration of pain medication, if needed
  • If necessary, blood and plasma transfusions for severe cases
  • Medications to control blood pressure
  • Peritoneal dialysis for acute kidney failure, if required
  • Providing life support, such as ventilation assistance and treatment for shock, for those with severe symptoms leading to potential organ failure
  • Rehabilitation of the affected limb through physical therapy, if required
  • Unless infection or tissue necrosis is observed, the administration of prophylactic antibiotics is generally not recommended in snake bites. However, the healthcare provider will determine whether antibiotics administration is necessary or not, based on one’s individual circumstances


  • Consultation with a medical toxicologist is recommended for all cases requiring the administration ofanti-snake venom
  • Even though antivenom therapy is the key treatment for systemic envenomation; on its own, it may never be adequate enough to completely resolve the condition. Other supportive and symptomatic measures are always necessary to save the patient
  • The dose of antivenom does not vary for a child, adult, or even for a pregnant woman, since the snake typically injects the same quantity of venom into an individual
  • Gynecological evaluation may be necessary for pregnant women bitten by sea snakes to evaluate the health of the fetus
  • In many instances, the type of venomous snake involved in the bite is unknown; hence, all vital organs and systems should be closely monitored and treated appropriately, as necessary

How can Dubois' Sea Snake Bite be Prevented?

Dubois’ Sea Snake Bitemay be avoided by:

  • Completely avoiding any sort of water or sea snake, especially in the endemic zones
  • Educating fishing and trawling community about sea snakes and the techniques for handling them, untangling them from fishing nets, etc.
  • Do not ignore warnings of lifeguards or health officials at the beach
  • Wear protective clothing if you plan to swim or dive in infested areas (suitable wet skin or diver’s suit)
  • Generally be aware or watchful of the waters you are in (to the extent possible)
  • Wear protective footwear while walking on beach sand
  • Ensure safety precautions while cleaning marine animal aquariums; wear gloves
  • Marine life explorers and sea adventurers are required to carry marine first aid kit
  • If you spot a sea snake (on land or in shallow waters), step back slowly and keep a safe distance between you and the snake
  • Be on the lookout for snakes and other animals while outdoors (especially while exploring small islands and rocky beaches); also, if you are with a pet, do not allow the pet to wander away
  • Be alert, if you are in snake-infested regions, particularly containing dangerous species of snakes
  • Avoid picking up sticks, stones, or rocks without checking the area for any concealed creatures
  • Ensure that employers provide adequate protective clothing (gloves, boots, etc.) to those who work in high-risk (for snake bite) occupations such as agriculture or fishing industry
  • Near coastal areas, always check before sitting on dead tree logs, stumps, or a pile of rocks; use a stick to stir or probe around the area
  • Avoiding being on beaches at night; be careful while camping outdoors by seaside
  • Avoid playing with or teasing snakes such as by touching their tails
  • Do not pick up dead snakes - they may be poisonous and still bite through a reflex action. Also, some snakes pretend to be motionless or may ‘act dead’ when under threat
  • Do not reach into dark nooks/corners/recesses with your bare hands/foot
  • Teach and educate children about the dangers and importance of snakes
  • Take steps to educate the members of a community to identify venomous snakes, recognize bite symptoms, and how to avoid encounter with snakes

Both large and small snakes have the potential for severe envenomation; hence, all snake bites should be treated promptly and appropriately.

Also, in case of a snake bite, do visit a registered medical practitioner immediately (and not any native or traditional medicine experts).

What is the Prognosis of Dubois' Sea Snake Bite? (Outcomes/Resolutions)

  • The prognosis of Dubois’ Sea Snake Bite is dependent on the site of bite, age and overall health of the individual, promptness of medical response, and continued observance and treatment of complications following admission of the patient. However, the overall prognosis is primarily based on the quickness with which suitable antivenom is administered
  • Without treatment or access to proper healthcare, deaths from severe complications, such as respiratory distress, severe paralysis, and organ failure may take place

Additional and Relevant Useful Information forDubois' Sea Snake Bite:

  • It has to be noted that snakes of the same species may vary in their physical and biological characteristics, including in their habitat and prey, from one geographical region to another. Due to this, it is always recommended to consult your local (zoological) expert to understand or evaluate the nature of the snake, including whether it is venomous or non-venomous
  • In some cases, the snake bite may be a ‘dry bite’, meaning that even though there is a bite mark, no venom injection occurs. However, even for dry bites, the patient must be placed under observation and monitored closely for a period ranging anywhere from 12-24 hours, prior to discharge
  • Depending on the geographical region, either monovalent antivenom or polyvalent antivenom may be administered for systemic envenomation. Monovalent antivenom neutralizes venom of a single snake species only, whereas polyvalent antivenom can neutralize the venom of several snake species.
  • The snake venom is a highly complex mix of several proteins, enzymes, amino acids, peptide chains, fats, and even certain metals. The bite causing venom injection into the body may be categorized as:
    • Intramuscular injection: Long-fanged snakes have a potential for injecting venom directly into the muscles (this is highly infrequent though)
    • Intraperitoneal injection: When the snake bite involves the stomach or abdomen region
    • Intravenous injection: In very rare cases, the snake fangs may inject venom directly into a blood vessel, releasing venom directly into blood (posing an even greater danger than normal snake bites)
    • Subcutaneous injection: A majority of snake bites involve the subcutaneous skin layers (venom is injected just below the skin surface)

What are some Useful Resources for Additional Information?

References and Information Sources used for the Article:

Helpful Peer-Reviewed Medical Articles:

Reviewed and Approved by a member of the DoveMed Editorial Board
First uploaded: June 25, 2019
Last updated: June 25, 2019

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